Who We Are

Altor BioScience Corporation is a biopharmaceutical company engaged in the discovery, development and commercialization of high-value, targeted immunotherapeutic agents for the treatment of cancer, viral infections, inflammatory and autoimmune diseases.

Our Focus

Altor currently has three products in clinical development. Our lead product ALT-801, a T-cell receptor-targeted immunotherapeutic developed from the STAR™ platform technology for cancer, concluded a Phase I/IIa clinical trial in patients with metastatic malignancies in 2009 (Fishman, et al. 2011 Clin Cancer Res 17:7765 - Pubmed Link) and a Phase II trial for ALT-801 in combination with cisplatin for patients with metastatic melanoma in 2012. A second Phase II trial for ALT-801 in combination with gemcitabine and cisplatin is enrolling patients with locally advanced or metastatic urothelial carcinomas of the bladder, ureter, urethra and renal pelvis. A third Phase II trial is underway for ALT-801 in combination with gemcitabine for patients with non-muscle invasive bladder cancer who have failed BCG treatment. (More on ALT-801 - PDF...)

Altor’s second product ALT-836, a monoclonal antibody-based tissue factor antagonist, completed a second 90-patient, multi-center, randomized, placebo-controlled, Phase II trial for treatment of patients with Acute Respiratory Distress Syndrome and Acute Lung Injury, life-threatening, systemic inflammatory diseases. A dose-escalating Phase I/IIa clinical trial for ALT-836 in combination with gemcitabine has been completed for treatment of patients with solid tumors who failed the standard-of-care treatments. (More on ALT-836 - PDF...)

The newest product to enter clinical development is Altor’s ALT-803, a novel IL-15 superagonist protein complex, initiating first-in-human Phase I clinical trials for treatment of metastatic melanoma, refractory multiple myeloma, BCG-naïve non-muscle invasive bladder cancer and relapse of hematologic malignancy after allogeneic stem cell transplantation. The primary objective of these trials is to evaluate the safety and biological effects of ALT-803 in a dose escalating design using a weekly dosing regimen. Patient enrollment in the clinical trials for treatment of patients with refractory metastatic melanoma, BCG-naïve non-muscle invasive bladder cancer and relapse of hematological malignancies after allogeneic stem cell transplantation have been initiated. Furthermore, Altor is actively engaged in multiple promising research collaborations with leading U.S. institutes and universities to explore the effects of ALT-803 against various diseases including cancer and viral indications, such HIV-1 and HSV-1.(More on ALT-803 - PDF...)

Numerous product candidates that have completed proof-of-principle studies in animal models are in pre-clinical development for treatment of cancer, infection, inflammatory and autoimmune diseases.

Overview and History

Altor was formed in 2002 by Hing C. Wong, Ph.D., as a spin-off from Sunol Molecular Corporation (“Sunol”), and is backed by leading venture capital funds, including Sanderling Ventures and the Florida Growth Fund. The Company has three proprietary technology platforms: the STAR™ platform, Tissue Factor antagonist platform, and IL-15 superagonist and scaffold technologies.

The STAR™ platform has been in development for over twenty years. Drs. Wong and Peter Rhode, Ph.D., Vice President of Research and Development, began developing the STAR™ platform while at Baxter Healthcare and continued its development at Sunol Molecular Corporation. Altor’s STAR™ technology is founded on a unique platform of proprietary technologies and skills that facilitate the rapid manipulation and development of soluble T-cell receptors (“TCR”) and major histocompatibility complex molecules (“MHC”). Altor employs this platform to improve the safety and efficacy of existing therapeutic drugs. The Company believes that its clinical development strategy of evaluating these drugs in their approved indications will minimize risk and facilitate rapid progress in clinical trials. The Company has secured its position with both a strong intellectual property portfolio and a pipeline of promising drug candidates. A team with extensive experience and discipline in corporate finance, research and discovery, and product development, as well as regulatory and clinical affairs manages Altor.

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Management, Scientific Staff & Boards...


Altor’s operations are located in facilities totaling 27,500 square feet in the Miami/Ft. Lauderdale area of South Florida. These facilities contain fully equipped laboratories built and outfitted specifically for biopharmaceutical research and development activities.