Scientific Literature and Publications

• Use of STAR™ multimers in detecting tumor peptide antigens on human tumor cells and tissues

  Zhu, X., H. J. Belmont, S. Price-Schiavi, B. Liu, H. I. Lee, M. Fernandez, R. L. Wong, J. Builes, P. R. Rhode, and H. C. Wong. 2006. Visualization of p53264-272/HLA-A*0201 Complexes Naturally Presented on Tumor Cell Surface by a Multimeric Soluble Single-Chain T Cell Receptor. J Immunol 176: 3223-3232. (Pubmed Link)

  Henrickson, S. E., T. R. Mempel, I. B. Mazo, B. Liu, M. N. Artyomov, H. Zheng, A. Peixoto, M. P. Flynn, B. Senman, T. Junt, H. C. Wong, A. K. Chakraborty, and U. H. von Andrian. 2008. T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat Immunol 9:282. (Pubmed Link)

  Henrickson, S. E., T. R. Mempel, I. B. Mazo, B. Liu, M. N. Artyomov, H. Zheng, A. Peixoto, M. Flynn, B. Senman, T. Junt, H. C. Wong, A. K. Chakraborty, and U. H. von Andrian. 2008. In vivo imaging of T cell priming. Sci Signal 1:pt2. (Pubmed Link)

  Wong, H. C. 2010. Company Profile - Altor BioScience Corporation Biomarkers Med. (2010) 4(4), 499–504 (ISSN 1752-0363 10.2217/BMM.10.69 © 2010 Future Medicine Ltd) (Pubmed Link) (PDF Link)
  
  

• Efficacy studies using STAR™ anti-cancer agents

  Card, K. F., S. A. Price-Schiavi, B. Liu, E. Thomson, E. Nieves, H. Belmont, J. Builes, J. A. Jiao, J. Hernandez, J. Weidanz, L. Sherman, J. L. Francis, A. Amirkhosravi, and H. C. Wong. 2004. A soluble single-chain T-cell receptor IL-2 fusion protein retains MHC-restricted peptide specificity and IL-2 bioactivity. Cancer Immunol Immunother 53: 345-357. (Pubmed Link)

  Mosquera, L. A., K. F. Card, S. A. Price-Schiavi, H. J. Belmont, B. Liu, J. Builes, X. Zhu, P. A. Chavaillaz, H. I. Lee, J. A. Jiao, J. L. Francis, A. Amirkhosravi, R. L. Wong, and H. C. Wong. 2005. In Vitro and In Vivo Characterization of a Novel Antibody-Like Single-Chain TCR Human IgG1 Fusion Protein. J Immunol 174: 4381-4388. (Pubmed Link)

  Belmont, H. J., S. Price-Schiavi, B. Liu, K. F. Card, H. I. Lee, K. P. Han, J. Wen, S. Tang, X. Zhu, J. Merrill, P. A. Chavillaz, J. L. Wong, P. R. Rhode, and H. C. Wong. 2006. Potent antitumor activity of a tumor-specific soluble TCR/IL-2 fusion protein. Clin Immunol 121: 29-39. (Pubmed Link)

  Wen, J., X. Zhu, B. Liu, L. You, L. Kong, H. I. Lee, K. P. Han, J. L. Wong, P. R. Rhode, and H. C. Wong. 2008. Targeting activity of a TCR/IL-2 fusion protein against established tumors. Cancer Immunol Immunother 57:1781. (Pubmed Link)
  
  

• Phage-display methodology to improve affinity of STAR™ reagents

  Weidanz, J. A., K. F. Card, A. Edwards, E. Perlstein, and H. C. Wong. 1998. Display of functional alphabeta single-chain T-cell receptor molecules on the surface of bacteriophage. J Immunol Methods 221: 59-76. (Pubmed Link)
  
  

• Interleukin-15 (IL-15)

  Zhu, X., W. D. Marcus, W. Xu, H. I. Lee, K. Han, J. O. Egan, J. L. Yovandich, P. R. Rhode, and H. C. Wong. 2009. Novel human interleukin-15 agonists. J Immunol 183:3598. (Pubmed Link)

  Wong R.L., Liu B., Zhu X., You L., Kong L., Han K.P., Lee H.I., Chavaillaz P.A., Jin M., Wang Y., Rhode P.R., Wong H.C. 2010. Interleukin-15:Interleukin-15 receptor {alpha} scaffold for creation of multivalent targeted immune molecules. Protein Eng Des Sel. (Pubmed Link)
  
  

• Tissue Factor Antibodies

  Morrow, D. A., S. A. Murphy, C. H. McCabe, N. Mackman, H. C. Wong, and E. M. Antman. 2005. Potent inhibition of thrombin with a monoclonal antibody against tissue factor (Sunol-cH36): results of the PROXIMATE-TIMI 27 trial. Eur Heart J 26:682. (Pubmed Link)

  Negrouk, V., G. Eisner, H. Lee, K. Han, D. Taylor, and H. C. Wong. 2005. Highly efficient transient expression of functional recombinant antibodies in lettuce. Plant Science 169:433. (Journal Link)

  Welty-Wolf, K. E., M. S. Carraway, T. L. Ortel, A. J. Ghio, S. Idell, J. Egan, X. Zhu, J. A. Jiao, H. C. Wong, and C. A. Piantadosi. 2006. Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure. Am J Physiol Lung Cell Mol Physiol 290:L21. (Pubmed Link)

  Jiao, J. A., A. B. Kelly, U. M. Marzec, E. Nieves, J. Acevedo, M. Burkhardt, A. Edwards, X. Y. Zhu, P. A. Chavaillaz, A. Wong, J. L. Wong, J. O. Egan, D. Taylor, P. R. Rhode, and H. C. Wong. 2010. Inhibition of acute vascular thrombosis in chimpanzees by an anti-human tissue factor antibody targeting the factor X binding site. Thromb Haemost 103:224. (Pubmed Link)
  
  

• Single-chain MHC Complex

  Rhode, P. R., M. Burkhardt, J. Jiao, A. H. Siddiqui, G. P. Huang, and H. C. Wong. 1996. Single-chain MHC class II molecules induce T cell activation and apoptosis. J Immunol 157:4885. (Pubmed Link)